Center for Molecular Innovation and Drug Discovery

Design. Create. Innovate.


ChemCore offers computational, medicinal and synthetic chemistry services to support drug discovery research at Northwestern and externally. ChemCore’s dedicated staff of medicinal and computational chemists design and synthesize novel small molecules that are suitable for therapeutic development for collaborative projects with physicians and faculty scientists.

Cheminformatics and Molecular Modeling

• High Throughput Virtual Screening (HTVS) of diverse libraries for different therapeutic targets
• Structure Focus Pharmacophore Design, 3D-4D and higher order QSAR Model Building
• Scaffold Hopping and de novo design
• Construction of protein homology models and 3-D analysis
• High level Quantum Mechanical Computations of Small/Drug Molecules
• Method development
• Linux-based multi-node cluster, which is powered by four NVIDIA Tesla K40 GPU accelerator*

*Funding for the GPU Research Cluster was made possible by an Office for Research Equipment Grant.

Medicinal and Synthetic Chemistry

• Hit-to-lead chemistry
• Design and synthesis of novel analogs with improved potency, ADME and IP properties
• Synthesis of small numbers of hypothesis-driven compounds
• Synthesis of reference compounds
• Preparation of fluorescently-tagged molecules

ChemCore Advisory Committee Members

Sarki Abdulkadir, MD, PhD, John T. Grayhack, MD, Professor of Urological Research, Feinberg School of Medicine

John Crispino, PhD, Robert I. Lurie, MD, and Lora S. Lurie Professor, Professor of Medicine (Hematology and Oncology) and Biochemistry and Molecular Genetics, Feinberg School of Medicine

Elizabeth Eklund, MD, Professor of Medicine-Hematology and Oncology, Feinberg School of Medicine

Milan Mrksich, PhD, Henry Wade Rogers Professor of Biomedical Engineering, Professor of Chemistry, Professor of Cell and Molecular Biology, Weinberg College of Arts and Sciences

Andrew Ott, PhD, Director of Core Facilities, IMSERC Director; Faculty Director of ELSC, Research Associate Professor, Northwestern Office for Research

Ali Shilatifard, PhD, Chair, Department of Biochemistry and Molecular Genetics, Robert Francis Furchgott Professor, Professor of Biochemistry and Molecular Genetics and Pediatrics, Feinberg School of Medicine

Richard Silverman, PhD, Patrick G. Ryan/Aon Professor of Chemistry and Professor of Molecular Biosciences, Weinberg College of Arts and Sciences

Karl Scheidt, PhD, Professor of Chemistry, Weinberg College of Arts and Sciences, Professor of Pharmacology, Feinberg School of Medicine; Director of the Center for Molecular Innovation and Drug Discovery, Director of ChemCore

Gary Schiltz, PhD, Deputy Director of the Center for Molecular Innovation and Drug Discovery, Director of Chemistry for ChemCore; Research Professor of Pharmacology, Feinberg School of Medicine