Center for Molecular Innovation and Drug Discovery

Design. Create. Innovate.

SYNTHETIC & MEDICINAL CHEMISTRY INSTRUMENTATION

Our collection of state-of-the-art research instrumentation is designed to carry out our mission of providing chemistry services for drug discovery and chemical biology researchers. Contact the ChemCore team at drugdiscovery@northwestern.edu for questions and additional information on our collection.

 Acquity UPLC H-Class System
  Enables LC/MS analysis of reaction mixtures, samples, and final compounds.
 Gilson Preparative HPLC System with GX-27L liquid handler*
  Enables reversed-phase high performance liquid chromatography of samples and crude mixtures.
*Office for Research Core Facility Equipment Award
Agilent high-throughput mass spectrometry-directed analytical to preparative LC purification system
  Mass-directed analytical-to-preparative (A2Prep) system for the analysis and purification of samples.
Agilent 1260 analytical HPLC with UV and ELS detection*
   Used for the analysis of samples and fractions.
*Office for Research Core Facility Equipment Award
Agilent 1200 Preparative HPLC
  Enables reversed-phase high performance liquid chromatography of samples and crude mixtures.
Columns Available for Use: ChemCore offers a wide variety of analytical, prep, and semiprep columns for an array of applications for your lab’s success. To view a list of available columns, click here. For column inquiries, contact our team at drugdiscovery@northwestern.edu.
Biotage Isolera Flash Purification System*
  Enables high performance flash chromatography of mixtures and samples.
*One of two acquired systems. Office for Research Core Facility ReLODE Award
 Biotage microwave reactor
  Enables microwave-assisted organic synthesis.
Biotage V-10 Touch System with Solvent Manager and 1 Automation
Vortex and vacuum evaporator which allows for rapid evaporation of both aqueous and organic solvents.
*Office for Research Core Facility Equipment Award
Genevac HT4 Centrifugal Evaporator
  A centrifugal vacuum evaporator capable of high performance on a variety of solvents.
 Genevac EZ-2 Plus centrifugal evaporator
  A centrifugal vacuum evaporator capable of high performance on a variety of solvents.
VirTis AdVantage Plus BenchTop Freeze Dryer
   A shelf lyophilizer capable of drying a large number of samples at once; compatible with non-standard vessels.
Parr Hydrogenator Apparatus*
 

Enables catalytic reactions with hydrogen at different pressures and temperatures.

*Office for Research Core Facility Equipment Award

 Thales Nano H-Cube hydrogenation system
  Capable of continuous-flow hydrogenation reactions.
ThermoFisher Water Purification System*
 

Produces ultrapure water for various applications including HPLC.

*Office for Research Core Facility Equipment Award

 Forma 8690 -80 °C Freezer
  Used to store final compounds at low temperatures.
In addition to this instrumentation, we also use the following software: eLN (electronic lab notebook), CDD (Collaborative Drug Discovery data management system), and TriposBenchware 3D Explorer Visualization Software (molecular modeling and computational chemistry software).
 For instrumentation used by our Cheminformatics Specialist, click here.